Mouse CD46-mIgG2a-CD Moleculars-Cambridge Bio

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Mouse CD46-mIgG2a

Cat No.:    03-01-0423
Product Name:    Mouse CD46-mIgG2a
Size:    50 μg
Price:    $229

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Cat No.: 03-01-0423
Product Name: Mouse CD46-mIgG2a
Description: CD46 is the membrane cofactor protein that serves as an inhibitory complement receptor in complement regulatory cascade.It acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. CD46 serves as receptor for adenovirus subgroup B2 and Ad3, cultured measles virus and herpesvirus 6,and pathogenic bacteria Neisseria and Streptococcus pyogenes.
Type: Protein
Property: Recombinant Protein
Source: HEK293
Genbank No.: O88174 ( aa.45-329)
Applications: ELISA, WB, Immunogen
Formulation: Each vial contains 50ug purified protein(1mg/ml) in PBS(pH7.4).
Purity: >95%
Storage: Store at -80°C, Avoid freeze / thaw cycle.
Limitation: For research use only, not for use in diagnostic procedures.