Mouse CD365-mIgG1-CD Moleculars-Cambridge Bio

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Mouse CD365-mIgG1

Cat No.:    03-01-2373
Product Name:    Mouse CD365-mIgG1
Size:    50 μg
Price:    $229

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Cat No.: 03-01-2373
Product Name: Mouse CD365-mIgG1
Description: TIM-1 is a member of TIM type I cell-surface glycoproteins, which include an N-terminal immunoglobulin (Ig)-like domain, a mucin domain with distinct length, a single transmembrane domain, and a C-terminal short cytoplasmic tail.TIM-1 is preferentially expressed on Th2 cells and has been identified as a stimulatory molecule for T-cell activation.TIM genes are also involved in host-virus interaction. As receptors for phosphatidylserine, TIM proteins bind many families of viruses [filovirus, flavivirus, New World arenavirus and alphavirus] that include viruses such as dengue and ebola. Interestingly entry of Lassa fever virus, influenza A virus, and SARS coronavirus were not affected by TIM-1 expression. TIM-1 and TIM-4 enhanced viral entry more than TIM-3.TIM-1 serves as a receptor for hepatitis A virus (PubMed:9658108),Ebola virus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871),and Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane.
Type: Protein
Property: Recombinant Protein
Source: HEK293
Genbank No.: Q5QNS5 ( aa.22-237)
Applications: ELISA, WB, Immunogen
Formulation: Each vial contains 50ug purified protein(1mg/ml) in PBS(pH7.4).
Purity: >95%
Storage: Store at -80°C, Avoid freeze / thaw cycle.
Limitation: For research use only, not for use in diagnostic procedures.